TERMIS Asia Pacific Meeting 2011

Tissue Engineering and Regenerative Medicine International Society Asia Pacific Meeting 2011

Hair Cycle Stages Classification And Gene Expression Patterns Of Regenerated Human Transplanted Hairs

JW Oh , JC Kim , JO Lim , M Kim
The hair follicle is a complicated organ, which has cyclic changes from anagen, catagen to telogen. Especially hair is the site that mesenchymal cells closely interact with epithelial cells. It is significant for any skin biologist to draw a detailed picture of the each stages of the human hair cycle. The aim of this study is to know the cyclical changes after human hair transplant. To understand those, we transplanted human scalp hairs in immune-compromised nude mice and analyzed the histological changes with time and immunological study. We could conclude after hair transplant, the hair follicle goes into dystrophic catagen. After 3 weeks, the epithelium enters apoptosis and dermal papillae get rounder than the anagen VI ones. 5 weeks later, some HFs are entering new anagen and we could find some important gene pattern. In 7 weeks, most of HFs are in the anagen III to VI. After 12 weeks every follicles are in anagen VI which is similar with in vivo hair follicles. We could make the model of human hair cycle using hair transplanted nude mice in formal study. We could identify each moment of programmed hair regeneration. This research can identify the genes those are differentially regulated at different stage of the hair follicle. This model could be used to study physiology of human hair follicle cycle as well as epithelial mesenchymal interactions of human hair stem cells.
Date: 4th August 2011 Time:1800-1815
Venue: Waterfront Ballroom III, Grand Copthorne Waterfront Hotel
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Hair Biologist, Hair Transplantation Surgeon, Medical Scientist